While working a SharePoint having heavy load got an issue for few users while opening documents/excel sheets/ PowerPoint in office client applications. Files that are stored in SharePoint, while opening files in client application got the following error:
Could not open "http://Servername/Documents/Doc".
After digging into the issue, found that SharePoint Workspace temp files are stored in Office Cache location which is used for synchronizing as stored in the location below,
By cleaning the temp files we can fix this issue.